double helix made of circuits

Identifying Risks While Reducing Cost and Time

At Cardio Diagnostics, we aim to identify those at risk for an acute event prior to its occurrence and subsequently guide individualized prevention interventions without the need to rely on costly, timely, and a multitude of less-sensitive tests. Our tests allow primary care practitioners to offer state-of-the-art clinical care by determining each individual’s unique environmental and genetic risks for the top 10 leading causes of death, including coronary heart disease and stroke.

Applications for Cardio Diagnostics Tests

For prevention of coronary heart disease, stroke, and congestive heart failure.

Diagnose

Determine presence or absence of Coronary Heart Disease and Congestive Heart Failure

Assess Risk

Determine risk for disease well in advance of an acute event such as a heart attack or stroke

Personalized Interventions

Determine combination of medications and lifestyle modifications to reduce risk

Monitor

Monitor disease progression and/or how interventions are reducing risk over time

Advantages of Cardio Diagnostics Tests

Patent-pending technology using artificial intelligence-derived genetic and epigenetic biomarkers to develop highly sensitive, fast, and affordable blood tests.

Prevention

Not everyone at risk has conventional risk factors (e.g. high blood pressure, cholesterol, smoke, etc.). For millions of people, the first sign is an acute event such as a heart attack or stroke.

Comprehensive

In addition to informing a patient of a general diagnosis and prospective risk, our tests can also inform personalized interventions because the biosignatures map to a combination of modifiable risk factors (e.g. cholesterol). Because DNA methylation is dynamic, our tests can monitor response to interventions and treatments.

Affordability

We estimate our tests will cost $500 or less, compared to hundreds or thousands of dollars for current approaches.

Ease of Implementation

Our tests require only 100 µl of whole blood, do not require fasting, and do not involve complicated lab or computational techniques, unlike current approaches that require large amounts of blood. We prepare DNA from the extracted blood, apply the ddPCR™ panel, and upload the output to a server to diagnose disease, assess risk, and recommend personalize interventions.

High-Sensitivity

Heart disease and stroke arise from the complex interplay of a number of lifestyle factors (e.g. dietary fat intake, smoking, sedentary activity levels) with underlying genetic variation. Our technology is more sensitive than the current standard (>30% for CHD1) because it simultaneously captures both genetic and environmental (lifestyle) complexities, the latter of which can be measured epigentically.

Speed

In less than 12 hours, our tests dramatically reduce time for clinician-initiated, personalized interventions from days to hours.

Flexibility

While our tests runs on the BioRad system, we can adapt them to other systems.

Scalability

Because our tests can run DNA from as little as a drop of blood, they can be easily scaled using pin-prick technology. Much of the sample processing can be automated, thereby improving throughput. Our tests can be performed across many testing facilities to accommodate increasing demand.

Integration with other Technologies

Because biosignatures map to a combination of modifiable risk factors, in the future they can be coupled to technologies and therapies for risk modification.